Projects

Selected project we participate(d) in:

*Project*	*Description*	*Partners*
	The first public domain database for diabetes drugs. In silico prediction methods represent an efficient approach for the prediction of diabetes drugs, aiming to explain preclinical drug development and therefore enabling the reduction of associated time, costs and experiments. DIA-DB is a web application for the in silico prediction of diabetes drugs, which uses two different approaches: comparison by similarity with a curated database of anti-diabetic drugs and experimental compounds inverse virtual screening of the input molecules chosen by the users against a set of protein targets identified as key elements in diabetes. The server is open to all users. registration is not necessary, and a detailed report with the prediction results is sent to the user by email.	Bioinformatics and High-Performance Computing Research Group Universidad Católica San Antonio de Murcia (UCAM), Spain
	“Addressing joint Agro- and Aqua-Biodiversity pressures Enhancing SuSTainable Rural Development” (aka BEST) is the project approved under Priority Axis 2 Integrated Environmental Management, Specific Objective 2.2, “Improvement of joint management and governance plans for biodiversity of coastal and rural ecosystems, paying attention on natural resources and protected areas and development of environmental“, under the INTERREG Greece–Italy 2014-2020 programme.	Region of Ionian Islands Region of Epirus
	The “PROTECT” project is aiming to provide insight on the chemical space requirements to develop selective modulators for the undruggable oncogenic Intrinsically Disordered Proteins (IDPs) and to generate programmable, cancer selective and cancer responsive drug delivery vehicles for their selective transport in cancer cells.	University of Florence, Italy Imperial College London, UK Stanford University, USA
	The main scope of the ExploreOpuntia project is the exploitation of different genotypes of the Greek varieties of Opuntia (Opuntia ficus – indica) by implementing various processes in order to obtain higher value-added products. Compared with other plants, Opuntia provides a wide range of exploitation potential due to the processing ability of various parts of the plant. The present project focuses on the integrated use of Opuntia to produce powders, isolate different colorants, encapsulate mixtures of sugars/colorants, isolate edible oil, and to produce bio-products from the young cladodes (flattened stems) or nopalitos, from the cactus, seeds fruit, and the peels.	Agricultural University of Athens (Coordinator) E.J. Papadopoulos SA Unilever Knorr SA PAXMAN LTD
	The main scope of the Epirustonic project is the development of a natural mineral water product, enriched with antioxidant herbal ingredients collected from the region of Epirus.	Vikos – Epirotic Bottling Industry S.A. (Coordinator)
	The main scope of the Epirus Cosmeceuticals project is the exploitation of pharmaceutical and aromatic plants of the Region of Epirus for the development of anti-aging preparations and functional dairy products.	Help Pharmaceuticals S.A. (Coordinator) Zagori – Dairy Products
	The main scope of the Beans project is the improvement of the nutritional value and the distinct dietetic characteristics of the greek legume variety Pyrgetos with the employment of specialized cultivation methods.
	FOODBIOMES is a new distributed research infrastructure of the Agri-food sector established in Greece that aims to offer world class research, education and innovation services exploring the impact of microbiome applications in food systems.	Democritus University of Thrace (Coordinator) University of Aegean Ionian University

The full list of our projects:

Targeting intrinsically disordered proteins in different cancers with natural products isolated from Epirus.
Biocatalytic development of novel hybrid molecules with improved cardioprotective properties: Targeting the Na⁺, K⁺-ATPase.
Unit for isolation/synthesis and rapid evaluation of bioactive molecules targeting orphan receptors for the therapy of cancer.
Synthesis of non-toxic calixarene derivatives, immobilization onto gold nanoparticles, and utilization and imaging as targeted biological cargo transportation in living cells.
Screening platform for discovery of small molecules targeting intrinsically disordered proteins (SPEED).
Pharmacological angiotensin AT2 receptor stimulation as a novel therapeutic approach in spinal cord and brain injury.
Biological evaluation of the anticancer activity of bioactive natural products, their analogues and formulations.
Exploitation of cactus pear fruit and leaves focusing on innovative food applications (ExploreOpuntia).
Bioinformatic analysis of large volume of genetic data of patients with brain tumor and development of advanced algorithms for the discovery of biomarkers and the prediction of possibility for cellular mutations (BIOPREDICTOR).
Exploitation of pharmaceutical and aromatic plants of the Region of Epirus for the development of anti-aging preparations and functional dairy products (EpirusCosmeceuticals).
Synthesis of fluorescent probes emitting in the near-infrared region and conjugation with bioactive molecules such as peptides and drugs.
Rational design, synthesis and biological evaluation of “smart molecular devices”, therapeutic and theragnostic agents that sense and treat cancer.
PROgrammable, cancer TargEted and Cancer responsive therapeutics and Theranostics (PROTECT).
Development of a natural mineral water enriched with antioxidant herbal ingredients from the region of Epirus (Epirustonic).
Dairy Products Supplemented with Natural Substances from Epirus (BIOPLEXED).
Addressing joint Agro- and Aqua – Biodiversity pressures Enhancing SuSTainable Rural Development (BEST)
Improvement of the nutritional value and the distinct dietetic characteristics of the greek legume variety Pyrgetos with the employment of specialized cultivation methods (Beans).
Infrastructure of Microbiome Applications in Food Systems (FoodBiomes).

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